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Differentiating between septic arthritis and transient synovitis of the hip in children: an evidence-based clinical prediction algorithm.
Kocher MS, Zurakowski D, Kasser JR. The Journal of bone and joint surgery. American volume 1999 · PMID 10608376 · doi:10.2106/00004623-199912000-00002
Cohort studyDiagnosisInfectionCitation checked
- Question
- Which clinical and laboratory features distinguish septic arthritis from transient synovitis of the hip in children?
- Design
- Retrospective single-centre cohort with multivariable analysis to derive a clinical prediction rule.
- Patients
- Children presenting to a US paediatric hospital with an acutely irritable hip.
- Intervention
- Four predictors: history of fever (>38.5 C), non-weight-bearing, ESR >40 mm/h, serum WCC >12 x10^9/L
- Comparison
- Final diagnosis of septic arthritis vs transient synovitis
- Primary outcome
- Predicted probability of septic arthritis by number of predictors present
- Key result
- The probability of septic arthritis rose steeply with the number of predictors present, being very high when all four were present and very low when none were.
- Limitations
- Retrospective derivation at a single tertiary centre; later validation studies found lower predictive performance, and CRP was not included.
- Impact on practice
- The classic decision aid for the irritable hip, taught universally; used alongside ultrasound and aspiration rather than as a stand-alone test.