UK-REBOAJAMA 2023
Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage: The UK-REBOA Randomized Clinical Trial.
REBOA did not reduce mortality; the Bayesian analysis showed a high probability of harm, with more deaths, many occurring early from bleeding.
Randomised trialManagementMajor trauma & polytrauma
PROPPRJAMA 2015
Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial.
There was no significant difference in 24-hour or 30-day mortality, but the 1:1:1 group achieved haemostasis more often and had fewer deaths from exsanguination in the first 24 hours, without more complications.
Randomised trialManagementMajor trauma & polytrauma
CRASH-2 timing analysisLancet (London, England) 2011
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
Treatment within 1 hour, and between 1 and 3 hours, significantly reduced bleeding deaths, whereas treatment after 3 hours appeared to increase the risk of death from bleeding.
Randomised trialManagementMajor trauma & polytrauma
Damage control orthopaedics (Scalea)The Journal of trauma 2000
External fixation as a bridge to intramedullary nailing for patients with multiple injuries and with femur fractures: damage control orthopedics.
Patients managed with external fixation were more severely injured, yet the staged approach was safe with low conversion complication rates, supporting its use in unstable patients.
Cohort studyManagementMajor trauma & polytrauma